Inhaled Selective Pulmonary Vasodilators for Advanced Heart Failure Therapies
نویسندگان
چکیده
منابع مشابه
Emerging Drug Therapies for Heart Failure
Heart failure is associated with high morbidity and mortality and is proving to be an economic burden in developing countries. A number of therapeutic agents are presently employed in heart failure; but they are not sufficient to control symptoms of heart failure. Moreover, the prevalence of chronic heart failure is progressively increasing and thus there is a continuing need to develop effecti...
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The inhaled route has a number of attractive features for treatment of pulmonary hypertension, including delivery of drug directly to the target organ, thus enhancing pulmonary specificity and reducing systemic adverse effects. It can also improve ventilation/perfusion matching by dilating vessels supplying ventilated regions, thus improving gas exchange. Furthermore, it can achieve higher loca...
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1. Sarnoff SJ, Berglund E: Neurohemodynamics of pulmonary edema. IV. Effect of systemic vasoconstriction and subsequent vasodilation on flow and pressures in systemic and pulmonary vascular beds. Am J Physiol 170: 588, 1952 2. Imperial ES, Levy MN, Zieske H Jr: Outflow resistance as an independent determinant of cardiac performance. Circ Res 9: 1148, 1961 3. Sonnenblick EH, Downing SE: Afterloa...
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ژورنال
عنوان ژورنال: The Journal of Heart and Lung Transplantation
سال: 2021
ISSN: 1053-2498
DOI: 10.1016/j.healun.2021.01.1766